The French and Indian war, also known as The Seven Year war had  huge affect on the Native Americans. Native Americans.  The war was between the French and British but affected the tribes in  the Ohio and Mississippi river region.Many of the tribes choose side and fought with them.Despite their hard efforts the French lost the war, this result had set the sad fate of the Native Americans. The French had an alliance with Native Americans and this allowed them to coexist without any problems. When the French lost to the British they also lost their land to them. This caused the Native Americans to eventually be pushed further west or killed.